Sentence examples for binding at least in from inspiring English sources

Interestingly, we found that TfCel5A active site could only partly rebalance its conformational dynamics upon substrate dissociation within the same simulation time, which implies that the conformational rebalance upon substrate dissociation is likely more difficult than the conformational selection upon substrate binding at least in the view of the time required.

A schematic representation of the selected promoters, with the position of the predicted C/EBP sites and the results of the ChIP experiments are shown in Fig. 2. Ten loci were enriched, one –Gata3- was modestly enriched, and LTBP and BCOR did not show credible binding, at least in the region we analyzed.

Thus, metformin impairs HSF1 DNA binding at least in part through blockade of its nuclear translocation.

Furthermore, Snail can suppress p53 by direct binding, at least in certain settings [ 61, 62].

Recent observations suggest a weak or no significant correlation between transcription and MSL complex binding, at least, in salivary glands (Kotlikova et al. 2005; Legube et al. 2006).

In particular, two glutamic acid residues are probably involved in direct Ca2 + binding, at least in TMEM16A and TMEM16F [12,24].

Although the idea of loci-specific chromatin architecture dictating HSF1 DNA binding remains hypothetical, we propose that the stress responsive acquisition of DNA binding competency, at least in the context of the Hsp70 and Hsp25 promoter, serves as an additional level of regulation in the overall model of the HSF1 activation pathway.

It is not unusual for chromatin-associated proteins to have broad binding specificities, at least in vitro (Davidovich et al., 2013; Kaneko et al., 2014).

We could thus show that the known differences between SOD1 and non-SOD1 ALS regarding TDP-43 pathology [ 9] are also reflected at the level of TDP-43 binding miRNAs, at least in LCLs.

In our previous study we showed that SGI bound to ssDNA primers and suggested that the binding could at least in part contribute to the inhibitory effect of SGI in qPCR assays [ 5].

A second tetramethylrhodamine-labeled double mutant (D63C/K216C) has more than 10-fold higher ADP affinity than the (D63C/D224C) mutants (data not shown), suggesting that weakened ADP binding is at least in part due to the mutation D224C.