Sentence examples for binding at high concentrations from inspiring English sources

However, when tested for its ability to down-regulate receptors, ondansetron caused chronic inhibition of binding at high concentrations.

At both concentrations, CREB1 increased GABPα-GST binding, but this enhancement is less than that observed for GABPα-GST binding at high concentrations (30 ng), indicating that GABPα-GST binding at 2.5 ng to the canonical motif is not saturating.

Non-specific binding at high concentrations precluded detailed fitting of these data (supplementary Fig S7 online), but the curves show that binding of Ub to USP4CD has a slower off-rate than that of Ub to USP4 D1D2, and together with the Kd value also suggest that it has a slower on-rate.

Surprisingly, wild-type CS/DS significantly reduced the binding of Fgf7 to keratinocytes in a concentration dependent manner unlike the Dcn−/− CS/DS that only affected the binding at higher concentrations.

A "scrambled peptide" harboring the same amino acid composition as PB11 25A but with the order randomized, did not block PA-HA binding at highest concentrations (3000 nM, data not shown).

However, if the daptomycin concentration was increased to 5 μM, there was a membrane area expansion indicating daptomycin binding at higher concentrations in the absence of Ca2+ ions.

Slight inhibition of radioligand binding at higher concentrations may indicate some interaction between the MPEP site and the putative site of action of these PAMs.

However, BODIPY FL vindoline (20) displayed binding saturation at high concentrations, which was not seen for high concentrations of BODIPY FL vinblastine (4).

To reduce the nonspecific binding, especially at high concentrations that could be a source of false positives when screening fragment libraries, it is important to find a suitable reference surface.

The ratios of non-specific binding to total binding approached unity at high concentrations for each probe.

Therefore, the net outcome of stimulating ARs on immune cells strongly depends on the receptor engaged and, therefore, on the receptor expression pattern (which might change during the course of inflammation [ 4, 45]) and neurotransmitter concentration, because NE binds preferentially to α-ARs, only binding to β-ARs at high concentrations (for example, [ 99]).