Sentence examples for binding at different sites from inspiring English sources

Other strategies with small molecule inhibitors binding at different sites, such as an allosteric pocket away from the interface, would be necessary to disrupt PPIs with large conformational rearrangements.

The first question relates to binding at different sites; the second relates to binding at similar sites.

Similarly, when considering an individual relative with multiple protein partners, it may be beneficial to have these partners binding at different sites, to reduce cross effects, unless binding to a common site was somehow important for regulation.

These effects are typically approximated by multiplying or summing separate Hill functions; however, in contrast to the thermodynamic formalism, this does not accurately represent multiple binding at different sites (Sherman and Cohen, 2012).

This behavior suggests that PK11195 and PpIX binding sites are interacting and that cholesterol is also altering the PpIX binding in manner that is somewhat additive with PK11195, consistent with partial overlap or allosteric effects of ligand binding at different sites.

In this work, we synthesized two fluorescent guest compounds (OVN and MVN) for supramolecular bindings at different sites with cucurbit[7]uril (CB7) and α-cyclodextrin (α-CD).

Ca2+-binding and nucleotide binding occur at different sites and stabilize distinct conformations of TGs.

The functional outcome is determined by subsequent co-regulator, co-activator, or co-repressor, binding events at different sites (6, 7).

From the mechanistic standpoint, we face two problems: first, if binding is at different sites, is it functional or nonfunctional, and second, if at similar sites, what is the outcome, activation or inhibition?

Do FOXP3 IRF4 complexes bind at different sites to FOXP3 GATA3 complexes and do the different binding partners lead to different local histone modifications and associated changes in gene activity?

Cooperative binding among TFs at different sites (including self-cooperative binding of the same species) can be characterised in the same way.