Sentence examples for binding at a subset from inspiring English sources
For ERG and CTCF, we further validated binding at a subset of these regions in primary tumor specimens by ChIP qPCR (Fig EV1B– E).
Motif analysis of the sites bound by both factors revealed a lack of the DR1 element, suggesting that TR4 binding at a subset of sites is facilitated through the ETS transcription factor ELK4.
DOI: http://dx.doi.org/10.7554/eLife.03549.018 To understand how reduced Zfp335 binding at a subset of direct targets in blt/ blt thymocytes could be biologically significant, we integrated our ChIP-seq data with gene expression profiles that we had obtained for blt/blt and wild-type mature CD4SP thymocytes.
In line with these observations, we found that Meis binding at a subset of regions bound by Hoxa2 in the IIBA Donaldsonn et al., 2012) was markedly increased in the IIBA compared to the IBA, while Pbx binding was only modestly affected.
With AA-ALIGNER, we were able to detect allelic imbalance in ChIP-seq data for a single transcription factor from a single cell line and provide supporting experimental evidence of differential protein binding at a small subset of imbalanced sites.
In this study, we report that HES6 maintains AR chromatin binding at a critical subset of sites, which are enriched for cell cycle regulatory genes under the control of E2F1, induces resistance to anti-androgens and castration and predicts poor outcome in the clinical setting.
We propose that this mechanism may account for maintained prostate cancer cell growth through concerted activity with the AR in HES6-driven androgen insensitivity, where the AR persistently binds to chromatin at a subset of binding sites and seems to be essential for the survival of the resistant cells, which cannot withstand AR knock-down.
Taken together this argues for a dynamic association of Xist RNA foci with stochastic binding to a subset of potential chromatin binding sites at a given point in time, rather than to a deterministic stable association at specific sites.
(B ) Ectopic expression of C/EBPβ in undifferentiated preadipocytes leads to MLL4 binding on a subset of C/EBPβ+ MLL4+ active enhancers identified at day 2 of adipogenesis.
