Sentence examples for binding at a distance from inspiring English sources
To uncover an explanation for how drug binding at a distance from the kinase active site could lead to inhibition and how inhibitors could combine their effects, hydrogen exchange mass spectrometry (HX MS) was employed to monitor conformational effects in the presence of both dasatinib, a clinically approved ATP-site inhibitor, and GNF-5.
These results are in agreement with the notion that CUX1 can perform some regulatory functions when binding at a distance from transcription start sites.
The ATG start codon is preceded by a putative ribosome binding site at a distance of 8 bp.
Consider (2) B P 2 = ∑ i = 1 N − 1 2 − i + 1 ∑ k = 1 n i R I ¯ k 10 N − 1, where N and n(i) are the number of amino acids in this protein and the number of two RNA-binding residues at a distance i, respectively.
In this model, whilst most mutations affecting binding of Nm and Hi were located centrally on the CFG face of the protein, Val-39 involved in Opa binding, was located at a distance towards the bottom of the CFG face (Fig. 1A).
We had previously demonstrated that extracellular binding occurs either by direct attachment of bacteria or yeast to the neutrophil surface or by binding of these cells at a distance through cytonemes (dynamic thread-like membrane tubulovesicular extensions of neutrophils [ 32]).
The miR-619-5p miR-619-5p miR-619-5ped at a distance of six nucleotides downstream of the bindingng of the miR-5095 site is the majority of genes containing arranged umiRNA sites.
To allow simultaneous binding to a membrane-embedded VAMP and PtdIns4,5P2 to occur, the amino-terminal half of the VAMP SNARE motif must be able to reach its binding site, which is at a distance of around 50Å from the membrane surface.
From this analysis, we predict Creb, Tcf/Lef, Pou-domain containing transcription factors, Sox9, and Mef2a as novel co-factors (binding at a short distance) and co-regulators (binding at further distance) of proneural proteins.
This is sufficient to include amino acids in vicinity of the hapten binding pocket at a reasonable distance for reaction with a thiol-containing linker.
