Sentence examples for binding assessment from inspiring English sources

In vivo specific binding assessment studies are necessary to confirm the viability of a potential PET ligand in preclinical species prior to advancing into human studies.

Brain bio-distribution, while not impacting PET doability, is required to inform subsequent PET imaging studies such as specific binding assessment.

The aim of this research was to study different assay strategies in order to determine the most sensitive system for further application in epitope characterization and binding assessment.

To address these limitations, we explored a previously reported liquid chromatography-mass spectrometry (LC-MS/MS) "cold tracer" protocol for in vivo specific binding assessment (Fig. 6) (Chernet et al. 2005).

For in vivo specific binding assessment, our earlier efforts employed the traditional in vivo radiotracer target occupancy (TO) protocol in rodents and used it as a pre-screen prior to advancing potential ligand leads to the more costly NHP PET imaging studies.

Most toxicologic studies have focused on the competitive binding assessment of environmental contaminants with T4, without evaluating their ability to modify transport protein synthesis.

Here, we use surface plasmon resonance (SPR) spectroscopy to make these peptide-peptide binding assessments.

The following dye combinations were added for 15 30 min at 37°C in the dark: a) 0.25 μg/mL annexin V plus 47.5 μg/mL PI in 500 μL binding buffer (assessment of apoptosis); b) 20 nM DiOC6 plus 2 μM HE (assessment of ΔΨm and mostly O2− production, respectively); c) 100 nM NAO plus 2 μM HE (to assess cardiolipin mass and O2− production, respectively).

This antibody binding affinity assessment, along with other molecular immunogenicity metrics, could be a key component of a computer-aided vaccine design strategy.

A clear disadvantage of this technique is that its accuracy enormously depends on the reliability of network construction and the veracity of binding affinity assessment.

For binding activity assessment the ascertained intensities of the bands were set in relation to the input of the pull-downs.