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The finger loop region has long been thought to be involved in receptor binding, as it undergoes movement upon receptor binding, and its flexibility is important for interaction with rhodopsin.
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The left part of Figure 1 shows some of the budding yeast proteins binding to a DSB as it undergoes HR repair and the right part shows some of the same proteins and telomere-specific proteins playing roles in telomere maintenance.
Glu311 is positioned in the C-terminal tail and acts to help anchor the tail to the large lobe as it undergoes structural rearrangement upon nucleotide binding to act as a regulator for access to the active site.
The Q149H suppressor may promote packing interactions within the large lobe to support anchoring of the C-terminal tail as it undergoes the structural transition during nucleotide binding.
Macy's said it will lay off 7,000 employees as it undergoes a massive restructuring.
Now, as it undergoes extensive refurbishment, it's even stranger.
It has been closed for nine months as it underwent a $3.2 million expansion.
"Treaties are, in effect, international law, and that's as binding as it gets".
After binding with estrogen, it undergoes an activating conformational change that promotes its homodimerization and nuclear transportation.
SNF likely undergoes conformational changes upon RNA binding, as well, much as U1A RRM1 undergoes a conformational change when bound to SLII (loop 3 protrudes through the RNA loop).
Upon binding to anionic PLs, it undergoes oligomerization to form a protective shield against coagulation enzymes.
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