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In this context it is noteworthy that Cdc13p, although very sequence specific, does not require a physical 3′ end for its binding, as it can bind single-strand TG1-3 DNA even if the telomeric DNA is on a circular plasmid (Lin and Zakian 1996; Nugent et al. 1996).
In fact, this region of p53 exemplifies the high potential of IDRs for multiple partner binding as it is known to bind more than 40 different partners.
The relatively low SC probably reflects a degree of protein binding as it is well known to bind with other proteins such as bacterial siderophores.
The finger loop region has long been thought to be involved in receptor binding, as it undergoes movement upon receptor binding, and its flexibility is important for interaction with rhodopsin.
"Treaties are, in effect, international law, and that's as binding as it gets".
In any case, the committee's view would not be binding, as it would be acting purely in an advisory capacity.
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On the other hand, the non-overlapping binding sites were the minor binding sites as it was judged by the low-level enrichment.
There is evidence that PFOS, similarly to PFDA, displaces the thyroid hormone from its binding protein as it circulates in the blood [115].
But when an inflation-averse central bank is trying to generate adequate demand when the zero lower bound is a binding or near-binding constraint (as it was in 2002-3 and is now) it just might.
In fact, the H epitope of the Leb and Ley antigens played a minor role in the binding outcomes as it does not at all participate in binding to Ley, or interacting with the Leb through a single H bond among the eleven H bonds in total.
Wild-type Dictyostelium discoideum (Dd) myosin II, however, shows no enhancement on the initial ATP binding steps as it lacks tryptophan residues near the nucleotide binding pocket.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com