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Platelet activation levels were assessed by measuring the expression of P-selectin (PS), a marker of degranulation, and fibrinogen (Fg) binding, as a result of integrin αIIbβ3 activation, on cell surface.
At low to moderate [K+] (60 100 mM), strong competition is observed between specific and non-specific binding as a result of a low specificity ratio (∼102) and a very small non-specific site size.
The linear association curves were caused by mass-transport binding as a result of low analyte concentration in the injection solution.
Any variation in binding or the total abrogation of binding, as a result of this adjacent Ser/Thr phosphorylation, may indicate that a stimulation-specific interaction exists between c-Cbl and its particular substrate.
Finally, covalently bound ligands are discarded, as we are interested exclusively in side-chain movements upon binding as a result of non-bonded interactions.
Decreased binding as a result of promotion of glucuronyl transferase activity is largely uninformative, again because the non-oxidized amine can be a substrate.
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The second model is that the PPARβ/δ-RXR heterodimer in association with co-activators and RNA polymerase II is dynamically binding chromatin as a result of the presence of an endogenous ligand or ligands, and available chromatin binding sites as a result of the activities of DNA modifying enzymes [ 15- 18].
Figure1 shows the dependence of the ground (n e = 1 and n h = 1) exciton binding energy as a result of the variation of the left-hand-barrier Al composition x Al 1.
However, given that the Sam68 binding-site mutants are still inducible (see Figure 2C), Sam68 phosphorylation appears to affect also other properties of the protein besides RNA binding, conceivably as a result of a conformational change.
Therefore, high nucleosome occupancy in this region would interfere with TFIIIB binding and as a result, pol III recruitment could be affected.
However, MPC has lost the mRNA binding domain, as a result down-regulating the activities of other PAM2 domain containing CID proteins (Tiwari et al. 2008).
More suggestions(16)
mandatory as a result
impediments as a result
consolidating as a result
binding as a homodimer
binding as a half-life
binding as a predictor
binding as a novel
binding as a heterodimer
binding as a mechanism
binding as a rate-limiting
binding as a trade
binding as a proxy
binding as a receptor
binding as a cause
binding as a consequence
binding as a sensor
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