EGFR represents a member of the cell surface receptor tyrosine kinase (RTK) molecular family, and it is activated upon ligand binding as well as receptor dimerization.
The first module consists of four ODEs and describes EGF binding as well as receptor homodimerization.
This is particularly useful for the modelling of transient, reversible interactions, such as ligand binding to a receptor, as it eases the tracking of individual molecular species.
Cywes and coworkers [ 90] reported that CD44, a hyaluronic acid binding protein that mediates human cell-cell and cell-ECM binding interactions, functions as a receptor for group A streptococci (GAS) colonization of the pharynx in vivo.
After binding of RANK (as a receptor) with RANKL (as its ligand), the receptor undergoes trimerization, which initiates an intracellular cascade, leading to cellular activation [ 26, 28].
Thus, intracerebroventricularly (i.c.v.) administered galanin was shown to reduce 5-HT1A receptor mRNA and 5-HT1A receptor binding, as well as galanin mRNA in the DRN with maximal effects 2 h after galanin administration (Razani et al. 2000).
An extracellular stimulus, such as a growth factor binding to a receptor, initiates a cascade of reactions that may terminate in the activation of a transcription factor (TF) that influences gene expression.
We have previously reported the in silico screening of 0.7 million compounds using the AnxA2 binding pocket of S100A10 as a receptor.
TRAIL is a naturally occurring cytokine that canonically acts by binding as a homotrimer to Death Receptor (DR -4 or -5, resulting in recruitment of aDR -4r morecules such as FADD and caspase-8.
Finally, genes co-expressed with Dp71 + Dp40 were enriched in terms related to receptor binding as well as vascular development.
