Sentence examples for binding as a proxy from inspiring English sources

Using ligand binding as a proxy of function, we show that the structure of ligand-binding sites significantly influences the evolution of protein complexes.

Our use of C4F6 binding as a proxy for disease relevance is, to the best of our knowledge, the first evaluation of the potential toxicities of SOD1 oligomers isolated in vitro.

Available evidence suggests that binding among Ago family members is not sequence-specific [43], [44] and so Ago2 binding was expected to serve as a proxy for binding with all Ago proteins.

Gerton et al. (2000) measured binding of Spo11 during meiosis as a proxy the rate of production of double-strand breaks.

With a high degree of interplay expected between tertiary and secondary structural changes [ 24], we evaluated the potential of infrared spectra as a proxy for binding capacity.

Because free kinesin heads in solution have a high affinity for ADP, whereas MT-bound heads exhibit a substantially lower affinity, the release of mantADP from kinesin heads serves as a proxy for the binding of free heads to MTs (Hackney, 1988, 1994, 2002; Gilbert et al., 1995; Hackney et al., 2003; Clancy et al., 2011).

Adjusting for Hb as a proxy for oxygen-binding capacity did not change the group mean estimates (data not shown); however, Hb was positively associated with CRF in women (P = 0.001) but not in men (P = 0.574), whereas men with higher Hb had higher PAEE (P = 0.038) but this association was not significant in women (P = 0.620).

The localization of a protein to these sites can serve as a proxy for methyl-CpG binding, and WT MeCP2 usually localizes there.

To do that we used as a proxy the number of binding sites for expressed miRNA present in transcription factors 3′ UTRs.

In these cases, ammonium can be used as a proxy for potassium to characterise potassium binding sites in enzymes: the H,N spin-pair of enzyme-bound NH4+ can be probed by N-edited heteronuclear NMR experiments.

Thus, identification and scanning of bound genomic regions by the ChIP targeted TFs and cofactors in vivo for transcription factor binding sites (TFBS) can be achieved and their co-occurrences used as a proxy for their interactions.