Sentence examples for binding as a dimer from inspiring English sources

By comparing the mobility of SOX9-DNA complexes with that of a binding site in an enhancer in intron 1 of Col2a1, we concluded that SOX9 was mainly binding as a dimer to each of the peak sequences.

LANA functions to tether the viral episomal DNA to host-cell chromosomes by binding as a dimer to terminal repeats of the viral DNA [6], [7] and to histone 2A and 2B bound to host-cell DNA [8].

The motif is an imperfect palindrome that can be represented as TGTYN8RAC, consistent with MrpC binding as a dimer.

PHR1 was first reported to regulate a small subset of Pi starvation-inducible genes in arabidopsis by binding as a dimer to the cis-element P1BS (GNATATNC) in the promoter region of its downstream gene (Rubio et al., 2001).

Ligand-bound GR can influence the expression of target genes, either by binding as a dimer to palindromic GC response elements (GRE) or tethering to other DNA-bound transcription factors [ 5, 6].

SRs are a class of ligand-activated TFs; they include a ligand-binding domain which activates gene expression in the presence of specific sex or adrenal steroid hormones and a DNA-binding domain, which binds as a dimer to palindromic REs consisting of two half-sites each six bases long (Bentley, 1998; Bain et al., 2007).

Gcn4p is a basic leucine zipper protein which interacts with DNA binding sites as a dimer [ 32], and is known to preferentially bind to several sequence motifs, including a 7-mer motif, TGACTCA [ 33, 34].

NFI binds as a dimer, and its preferred binding sequence is a palindrome composed of two half sites TTGGCANNNTGCCAA.

The HD of Pax6 preferentially binds as a dimer to the palindromic DNA binding site: TAATYNRATTA (Y is C or T; R is A or G; N is any nucleotide), which is known as the P3 site.

This is consistent with ATF3 binding as a homo-dimer and acting as a repressor of transcription but in a hetero-dimer with JunD it acts as an activator of the transcription [ 24].

Following the GC binding to the cGR, the receptor-associated proteins dissociate and the complex of GC/cGR translocates into the nucleus, binding as a homo-dimer to specific DNA binding sites, so-called GC response elements [ 13].