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Intriguingly, if correct, this model would directly implicate decreased HMG chromatin binding as a cause of necrosis instead of a consequence of necrotic cell death, as previously described [ 52, 64].
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A recent paper linked Aβ oligomers and FcγIIb receptor binding as a possible cause of neurotoxicity by activating caspase-12 and boosting endoplasmic reticulum stress markers [ 59].
Another FGFR3-specific monoclonal antibody under evaluation, R3Mab, inhibits ligand binding as well as causes changes to receptor confirmation.
We, and others, have recently identified mutations in the gene encoding the RNA-binding protein Fused in Sarcoma (FUS) as a cause of familial ALS (2– 16).
As a young man, he embraced the conviction that songs are a way of binding people to a cause.
Avoid use of bandage binding as this can cause damage to breast tissue and cause pressure on breathing.
The linear association curves were caused by mass-transport binding as a result of low analyte concentration in the injection solution.
They say a contract between two men is almost as binding as a handshake between them.
We were able to exploit this fact to develop a fluorescence-based measurement of heme binding as heme addition causes quenching of Trp fluorescence.
We studied promoter regions of human miRNA genes (intergenic as well as intragenic) for the potential effects that SNPs may have due to their overlap with putative TF binding sites (TFBSs) or as a potential cause for the creation of novel TFBSs on positions where no TFBS was mapped.
Deletion of the UIM motif caused a marked reduction in NEDD8-binding and had no effect on ubiquitin-binding, while UBA-deletion abolished ubiquitin-binding and caused some reduction in NEDD8-binding as well.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com