Sentence examples for binding area and the from inspiring English sources

From our understanding drawn from experience with the THIQ systems these compounds could well act as chimeras addressing both the steroidal A-ring binding area and the trimethoxyaryl binding area of the colchicine binding site on tubulin.

Different rigid ligand conformations were placed into the binding area, and all ligand conformations were minimized using the CHARMm force field.

A classic example is the EGFR inhibitor Gefitinib, where the quinazoline core occupies the adenine binding area and makes one hydrogen bond with Met793 in the hinge and two water-mediated hydrogen bonds with Thr790 and Thr854, respectively.

The nonspecific binding area, the cerebellum, showed no binding and half of the activity dissipated in 2.5 h.

According to this binding pose, compounds stretch across most of the binding area occupied by the N-terminus of the cognate AnxA2 ligand (Fig. 2c).

Induction by sophorose results in a loss of positioning of nucleosomes -1 and -2 downstream of the binding area, thus making the TATA box accessible.

These data suggest that 48scFv-SCR constructs may not interfere with the binding area on either the monomeric or trimeric form of gp70 and do not hamper infection at all.

The broad Tpk1 binding area ranges from the EFG1 transcriptional start site through 1169 bp untranslated upstream sequences and ends close to the 3′end of the EFG1 ORF.

DvM 334 conforms with other known cystatins [ 44] such that the molecule has three papain-binding areas and four conserved cysteines that create two disulfide bridges.

This indicates that the SAH binding area contributes significantly to the overall similarity of the two backbones, but that the remainder of the model is still in very good agreement with the complete structure.

The binding area for 118208 and 130813 (pocket 1) has been localized on the deep interaction interface between NBD1 and NBD2, and in the CFTR model is occupied by two loops from NBD2 domain.