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Despite the aberrant ID50 of one mutant clone, these results clearly demonstrate that WT levels of β3 chain integrin binding are not required for B. burgdorferi to establish disseminated infection at 4 weeks post-inoculation.
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Moreover, there are reports that suggest MutL does not bind to DNA at physiological salt and that DNA binding is not required for MMR [13], [14].
In 68 Ga-TRAP MDP 3 Ga-TRAP MDP 3P(PDP)3, TRandthus merely serves as a scaffold, and its ability for 68 Ga-TRAP PDP 3 Ga-TRAP PDP 3
Again, the cysteine residues directly involved in p56Lck binding were not required for PLSCR1 binding, since the CD4c peptides had alanine at these positions (Fig. 6A).
This result indicates that PtdIns(4,5 P2 binding is not required for internalization of the extracellular N-PTB and that N-PTBK53K90, with reduced sulfatide-binding properties (Fig. 1C), is likely internalized in an integrin receptor-dependent manner.
Therefore, VEGF-NRP1 binding is not required for developmental angiogenesis.
10.7554/eLife.03720.010 Figure 4. VEGF-NRP1 binding is not required for developmental angiogenesis.
We found NtA was synergistic with GST-VCA, demonstrating that actin filament binding is not required for synergy.
Rnd3-AllA coimmunoprecipitated with p190RhoGAP-B, similar to WT Rnd3, and thus 14-3-3 14-3-3 14-3-3t required for this interaction.
The compact exploration modes suggest that strong binding is not required to ensure high occupancy and that compact exploration factors may be preferentially shared between proximal loci.
These results suggested that Sp binding was not required for the recruitment of the ER-α to the adjacent AP-1 site.
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