Understanding side-chain flexibility upon binding is important to understand molecular recognition events and predict ligand binding.
As a result, the analysis of GR expression and binding was important to the evaluation of the response to GC therapy.
A caveat with these analyses, however, is that motifs that have low information content, either because they are short or because they have relatively low sequence specificity, will align to numerous places in a genome as large as human, so further contextual evidence, such as evidence of the relevant protein binding, is important to reduce false positives.
We show that taking explicitly into account the diffusion coefficients of the microstructure and the chloride binding capacity are important to consider for a better prediction of the time span until corrosion initiation.
Insulin and insulin-like growth factor (IGF -1 bIGF -1 properties are important to evaluate with any new insulin to ensure that the safety profile is not adversely affected bindingmolecular modifications introduced during the bioengineering properties135].
Extensive, additional contacts are made between the polybasic region and the reminder of p47phox, outside of the core superSH3 domain ligand binding site that are important to enforce the resting state.
Nevertheless, the effect of alanine substitutions at His395 and His478 on colistin susceptibility of producer strains indicates that, irrespective of their role in possible metal binding, both of these residues are important to the structure or activity of MCR-1.
Although the terms effective exposure and effective binding potential demonstrate the dual roles of plasma protein binding, it is important to note all three factors that affect specific binding in brain: F, B max, and K D (Eq. 2).
Whilst algorithms can predict peptide binding to particular HLA types and some assays confirm binding, it is important to demonstrate the full repertoire of functional HLA-peptide complexes.
While the molecular biology underlying condensin's binding mechanism is important to explore, our simulations are oblivious to the molecular details that underlie the interactions.
