Sentence examples for binding are difficult to from inspiring English sources
Our results thus indicate that properties related to binding are difficult to model from the employed representations of structure while catalytic mechanisms seem to associate well with conserved structural similarity (Table S4).
It is possible that VHH T5 10 has higher binding ability to the linker of coating antigens than VHH T1 4 and VHH T3 15 and this nonspecific binding is difficult to inhibit by free TBBPA.
This finding that p63 DNA-sequence motif is an important determinant of in-vivo binding is difficult to reconcile with the fact that p63 motif was not considered a strong predictor in our statistical models.
However, the binding affinities are difficult to measure and related works use transcription factor occupancy to approximate binding affinity [4], [5].
Such complicated binding situations are difficult to predict, because this method does not model the interactions between ligands.
Generally, persistent infections are characterized by an excess of viruses or virus antigens; free antibodies, which circulate without binding to antigens, are difficult to detect.
Judith A. Stein, director of the Center for Medicare Advocacy, a nonprofit group that counsels beneficiaries, said, "Most of the guidelines are phrased as recommendations or suggestions, not binding requirements, so they are difficult to enforce".
The binding experiments in vivo are difficult to evaluate in a quantitative manner.
A possible explanation is that at most promoters residual levels of H3K4me3 remain and these basal levels may be sufficient to partially retain Pol II binding, so that changes are difficult to detect (see Figure 4B).
The obvious benefit of this method is that the low sample requirement allows detection of SH2 binding in samples which are difficult to analyze using traditional protein interaction assays.
