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In either case, gal-1 binding appears to alter GRG conformation and perturb inter-glycan interactions.
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Conformational changes of OBP proteins upon ligand binding appear to alter their structure in such a way that the receptor can distinguish between the "loaded" and "empty" form of the OBP.
Thus binding of substrates appears to alter the accessibility or reactivity of Cys to labelling with the fluorophore.
Intriguingly, some of these new amino acids form a putative coiled-coil domain that appears to alter binding properties between Csd allelic proteins (Otte and Beye, unpublished results).
RPA is also known to undergo a significant conformational change upon binding DNA (22, 23) that appears to alter RPA's structure in a way that facilitates interactions with other proteins and ssDNA.
The rearrangement seen with the 357 372 dityrosine bridge appears to alter the zinc binding sites and open up buried binding sites that are not present in molecules lacking dityrosine bonds (Fig. 6B).
Overall, these results suggest that binding of drugs and lipid A to MsbA appears to alter the accessibility or reactivity of Cys to labelling with the fluorophore.
And people's satisfaction with their relationships appears to alter how they experience pain.
The processing of biologic scaffolds appears to alter macrophage phenotype.
The toxin appears to alter the vascular permeability as well, thus inducing oedema.
The metastoma also appears to alter its dimensions throughout ontogeny.
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