The intraluminal thrombus exerts its pathogenic effect through platelet activation, fibrin formation, binding of plasminogen and its activators, and trapping of erythrocytes and neutrophils, leading to oxidative and proteolytic injury of the arterial wall.
Site-directed mutagenesis has been central to the characterisation of cellulases, ranging from the identification and characterisation of putative catalytic and binding residues, the trapping of enzyme-substrate complexes by crystallography through to the construction of new and improved biocatalysts including 'glycosynthases'glycosynthases
At the same time, there was no evidence of significant chemical binding or trapping of DPPH in the PANI structure.
We speculate that the binding or trapping of TCR by the actin cytoskeleton network could also be instrumental in favoring the assembly of the TCR associated signaling cascade.
The time activity curves (TAC) from the dynamic PET-data show a rapid increase in the first frames followed by a plateau in the last frames as with specific binding or trapping of the tracer.
This is in stark contrast to the ABC homodimer, MsbA, where ATP binding and HES trapping stabilize the same conformation of the NBD dimer.
The presumed homolog of the thyroid in filter-feeding, non-vertebrate chordates is the endostyle, an organ located ventral to the pharyngeal floor that functions in iodine binding and secretion of food-trapping mucus [ 83].
In prokaryotes, factors that package DNA, such as HU proteins, may control supercoiling by binding to DNA and trapping the free energy of supercoiling as writhe and subsequently releasing it through controlled dissociation [ 3,4].
More complex scenarios may be envisaged, since for example neutrophils from CGD patients are also defective for extracellular bacterial killing, as they do not produce Neutrophil Extracellular Traps (NETs), involved in binding and killing of a variety of microbes (Papayannopoulos and Zychlinsky, 2009).
