Sentence examples for binding and translocation of from inspiring English sources

The bound ATP molecule was positioned between the catalytic site and the β3-β4 loopsuggestinging that the ATP binding can modulate the initial binding and translocation of dNTP and NRTIs into the catalytic site (Figures 3 and 4).

Our data imply that the ATP molecule and NRTI mutations can modulate the nucleotide selectivity of HIV-1 RT by influencing the geometric selection of nucleotides in the catalytic cavity, as follows: First, the presence of bound ATP molecule in the catalytic cavity can sterically influence the initial binding and translocation of dNTP/NRTI into the catalytic site.

CdtA and CdtC are required for receptor binding and translocation of the enzymatically active CdtB component.

CTS and Pxa1/2p also exhibit sequence asymmetry in TMDs which potentially influences binding and translocation of substrates.

These studies clearly suggest a coupling between the binding and translocation of these species during the transport cycle.

This has implications not only for ATP binding and hydrolysis but also for binding and translocation of the transported substrates.

It is therefore likely that under our experimental conditions translocation of the nucleosome itself rather than the binding to and translocation of RSC over bare DNA was rate limiting.

This demonstrates the competence of the binding and translocation domains of PE to mediate delivery of the DTA and RTA catalytic domains into cells cytoplasm and, importantly, that NS3 cleavage mediated enhancement in the enzymatic activity of the two zymoxins (as was detected by in-vitro assays) is practically translated to enhancement in cytotoxic activity.

DAB389IL-2 is a recombinant fusion product made of a portion of diphtheria toxin, which contains binding and translocation components of the toxin linked to IL-2.

This construct was then fused in its N terminus to the binding and translocation domain of PE, as the natural binding and translocation domain of ricin toxin (RTB) undergoes N-glycosylation when produced in Ricinus communis, which is necessary for its lectin activity.

By fusing RTA to the bacterially derived binding and translocation domains of PE, chimeric PE-RTA toxins that are capable of penetrating into the mammalian cell cytoplasm (demonstrated previously by Pitcher et al [52]) may be produced in E. coli by standard methods.