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The possible mechanisms by which tHcy may contribute to RVO include the activation of factor V, the increased oxidation of low-density lipoprotein, the inhibition of plasminogen activator binding, and the activation of protein C [ 62].
The results clearly showed that irradiation activates NF- κB binding and the activation is attenuated by CAPE.
Intracellular signal proteins are activated at a high level soon after ligand binding, and the activation level decreases in a negative feedback manner without ligand clearance.
The interaction force is poorly correlated with both the equilibrium free energy of biotin binding and the activation free energy barrier to dissociation of the biotin-streptavidin complex.
Several markers have been linked to calcium entry and binding, and the activation of signaling and phosphorylation cascades.
In order to elucidate whether Syx RhoGEF activity was important for VEGF-A/NRP1-induced DJM-1 cancer cell proliferation, we constructed a lentivirus vector encoding Syx WT or a Syx mutant with a point mutation at the position of 571 Leu replaced to Glu in order to lose binding and the activation of RhoA (Marx et al., 2005).
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33 TM6 contains a cluster of hydrophobic amino acids that are involved in agonist binding and in the activation of the GPCRs.
The physiological role of CRP consists in binding phosphocholine and the activation of the complement system leading to phagocytosis.
The Gerbera proteins were translationally fused separately to both the binding domain and the activation domain, and were combined in both directions.
Whereas B. abortus practically did not consume complement, O. anthropi completely abrogated the lytic activity, demonstrating an effective surface binding and the subsequent activation (Fig. 5A).
Previous studies found that Ca(2+ -binding sites and the activation gate are spatially separated in the channel protein, but the mechanism by which Ca(2+ -binding opensites gand over thes distactivationns unknown.
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