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Vascular ECM can be used therefore as a substrate for binding and retention of drugs delivered intravascularly, if these drugs are endowed with an ability to bind to the vascular ECM.
The results indicate binding and retention of the targeted contrast agent to tumor tissue.
Under normal conditions (low lysosomal pH and high nutrients), TFEB is inactivated by mTORC1-dependent phosphorylation, leading to 14-3-3 14-3-3 14-3-3etention of TFEbindinge cytopland [ 39].
Using zinc-based micromotors as a model, we demonstrate that the acid-driven propulsion in the stomach effectively enhances the binding and retention of the motors as well as of cargo payloads on the stomach wall.
Specific binding and retention of PiB in cortex has now been demonstrated in patients with AD, 7– 11 dementia with Lewy bodies, 11– 13 cerebral amyloid angiopathy, 9, 14 and subsets of mildly impaired 15, 16 or apparently unimpaired normal control subjects (NCS).
Amino acid sequence alignments for these opossum gene products with human CES isozymes demonstrated considerable conservation of key residues involved in catalysis, organelle localization, quaternary structure and ligand binding, and retention of the α-β secondary structures previously reported for human CES1 [ 3, 15, 29, 30, 43].
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First, the administration of soluble GAGs resulted in their binding to and retention of VEGF-A within the murine ocular fluid.
By incorporating a diazirinyl moiety in isoflurane, we produce a molecule that demonstrates photoadduction to residues in known anesthetic binding sites, and retention of normal in vivo and in vitro actions.
Microdosimetry was calculated based on binding and retention kinetics of 211At to the cells, as well as cellular and nuclear diameters.
Similar behavior, where a balance can be achieved between lithographic modification to enable the introduction of protein-binding functional groups and retention of resistance to nonspecific adsorption, has been reported previously for other PEGylated systems (including photodegradation of OEG-silanes and in the patterning of silanes protected with OEG-functionalized nitrophenyl groups).
These patterns of TNF binding and retention may reflect the number of TNF receptors or their affinity for TNF, as well as the balance between cell surface and soluble TNF receptors.
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binding and internalization of
binding and transport of
binding and activation of
binding and dissociation of
binding and effect of
binding and invoking of
binding and growth of
binding and regulation of
binding and dimerization of
binding and hemolysis of
binding and enactment of
binding and uptake of
binding and migration of
binding and stability of
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