Sentence examples for binding and receptor internalization from inspiring English sources

Single nucleotide polymorphisms c.980A > G (rs43323012) and c.995A > G (rs43323013) cause changes in the C-terminus (p.Lys327Arg and p.His332Arg) and might interfere with adaptin-2 binding and receptor internalization [ 12].

Several mechanisms are known to operate in desensitization of 5-HT2A receptors, including phosphorylation, arrestin binding and receptor internalization (Rahman and Neuman, 1993; Gray et al., 2003; Van Oekelen et al., 2003).

Sedaghat et al. combined models of insulin binding [ 36] and receptor internalization, recycling and degradation [ 35] and extended them to a mathematical model of insulin signaling in adipocytes [ 37].

Steps 1 11, which include Shc recruitment to the receptor, binding to the Grb2-SOS complex and receptor internalization, were adopted from the earlier study [26].

The described processes are successive binding of two insulin molecules to the insulin receptor, receptor phosphorylation and receptor internalization.

Cetuximab is a chimeric (mouse/human) monoclonal antibody that binds specifically to the epidermal growth factor receptor (EGFR), competing with ligand binding and promoting receptor internalization and downregulation [13].

The antibody blocks ligand binding and induces receptor internalization and degradation, resulting in down-regulation of surface EGFR expression.

The anti-EGFR mAb binds the extracellular domain of the receptor by competing with ligand binding, and by inducing receptor internalization and consequent degradation [ 36], thus reducing EGFR activation more efficiently than lapatinib.

In this study, model parameters (Table 1) are taken from previously published in vitro experiments [ 47, 49- 55] and small models of insulin binding [ 36], receptor internalization [ 34] and nonspecific hepatic insulin binding [ 46].

Hepatic insulin receptor activation by insulin binding, receptor internalization and autophosphorylation is explicitly included in the model.

The mechanism of clearance by the placenta most likely involves insulin binding to its receptor, internalization, and degradation.