Your English writing platform
Discover LudwigExact(3)
Chang, Y., Ghansah, E., Chen, Y., Ye, J. & Weiss, D. S. Desensitization mechanism of GABA receptors revealed by single oocyte binding and receptor function.
The first and third extracellular loops (ECL) of G protein-coupled receptors (GPCRs) have been implicated in ligand binding and receptor function.
Although I41 was universally important for binding and receptor function, the role of other residues depended on both ligand and RAMP.
Similar(57)
A clear correlation between cation−π binding ability and receptor function, as reported by EC50, indicates a functionally significant cation−π interaction.
The presence of residue F or D at position 502 for all four pteropodid NPC1 proteins tested was fully concordant with EBOV GP-NPC1 binding and NPC1 receptor function, and was also true for HsNPC1 (D, permissive; F, restrictive).
Earlier studies have shown that Green Fluorescent Protein (GFP) fusions to the N-terminus of CXCR4 do not disrupt CXCL12/SDF1 ligand binding or receptor function [35].
Our data showed that mutation of S163 to either Ala or Thr resulted in no significant changes to binding or functional parameters, suggesting this residue does not play a significant role in palonosetron binding or receptor function.
Differences in binding and effects on receptor function may explain some differences between palonosetron and the first-generation 5-HT3 receptor antagonists.
Based on these findings, we hypothesized that viruses from persistent infections could contain an HN with uncoupled receptor-binding and receptor-destroying functions: HN bound to receptors would not be released for binding another substrate as long as NA is not active and as a consequence incorporation of HN into viral progeny could be hindered.
The differences in binding and the effects on receptor function may explain the differences in the clinical effects between palonosetron and the first-generation 5-HT3 receptor antagonists.
Antibodies that block ligand binding or interfere with receptor function can directly inhibit the growth of cancer cells in addition to their potential to direct effector cells of the immune system to the tumor [ 3].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com