Sentence examples for binding and receptor dimerization from inspiring English sources

The extracellular cysteine-rich domains of ErbB2 receptors play important roles in ligand binding and receptor dimerization.

EGF binding and receptor dimerization are assumed to interact mutually.

Antibody inhibitors block the extracellular ligand binding domain of EGFR thereby preventing ligand binding and receptor dimerization.

According to thermodynamic constraints [ 33, 28], EGF binding and receptor dimerization have to interact mutually fulfilling the Wegscheider conditions.

The crystal structures of the ECDs of EGFR with bound ligand outline key aspects of ligand binding and receptor dimerization [ 18, 19].

Since our previous analysis, the solution of crystal structures of the extracellular domains from the receptors [ 43- 47] suggested a mechanism of ligand binding and receptor dimerization in which an intramolecular tether stabilizes the unliganded monomeric receptor and release of the tether allows a structural rearrangement permitting high affinity ligand binding and receptor dimerization [ 48].

Ligand binding, dissociation, and receptor dimerization rate constants came from Shankaran's model [ 39] and are found in Computational Methods.

The rate constants of ligand binding, dissociation and receptor dimerization as well as the reaction rate multiplier came from Shankaran's model [ 39](Table 2).

Archetypal NRs have a DNA-binding domain (DBD), which contains two C4 zinc fingers and mediates binding to specific DNA sequences and receptor dimerization, and a more C-terminal ligand-binding domain (LBD), which may bind a lipophilic ligand and functions in dimerization, nuclear localization, and transcriptional trans-activation.

On the one hand, we currently lack sufficient mechanistic insights into the coupling of external ligand binding events to kinase domain activation, and receptor dimerization alone is clearly not sufficient.

Normal (non-overexpressing) HER2 signaling is dependent on ligand binding and subsequent receptor dimerization, and promotes downstream activation of the PI3K-AKT and/or the Ras Raf MEK ERK1/2 axes.