Sentence examples for binding and receptor dimerisation from inspiring English sources

Members of the EGFR family contain a cytoplasmic tyrosine kinase domain, a single transmembrane domain, and an extracellular domain that is involved in ligand binding and receptor dimerisation (Ferguson et al. 2003; Olayioye et al. 2000).

Qing et al (2009) used shRNA knockdown and a newly developed antibody that prevents both ligand binding and receptor dimerisation and showed inhibition of RT112 xenograft tumour growth.

Structurally, the EGFR possesses an extra-cellular domain that is involved in specific ligand binding and receptor dimerisation, a single transmembrane domain, and a cytoplasmic domain that hosts intrinsic tyrosine kinase activity.

The C-domain (involved in DNA binding and receptor dimerisation) and the E domain (involved in ligand binding) showed a high degree of homology among receptors (94- 97% amino acid identity in C domain, 78-83% in E domain).

Equations relating to juxtacrine receptor – ligand interaction and receptor dimerisation and phosphorylation.

Fulvestrant ER binding impairs receptor dimerisation, and energy-dependent nucleo-cytoplasmic shuttling, thereby blocking nuclear localisation of the receptor (Fawell et al, 1990; Dauvois et al, 1993).

Ligand binding induces receptor dimerisation, activation of the kinase and phosphorylation of tyrosine residues in the cytoplasmic domain.

For instance, V16, V18 and V24, (which describe the maximal rate of Raf, Mek and Erk dephosphorylation respectively – see table 3), all had a significant influence on signal amplitude; by contrast, parameters describing the rate of receptor ligand binding, receptor dimerisation, activation and internalisation had a much less significant effect.

Upon ligand binding, receptor dimerisation activates tyrosine kinase activity and tyrosine autophosphorylation.

The RAR β2 anti-proliferative effect required only the ABC domain (AF1 and DNA-binding domains), and not the retinoid-binding domain or receptor dimerisation interface.

Ligand binding to the EGFR, receptor dimerisation and the activation of downstream signalling pathways are molecular events involved in tumorigenesis (Kim and Muller, 1999; Carpenter, 2000.