The evolutionary correlation between ligand binding sites, ligand structure and protein function has also been demonstrated by a network of ligand-binding-site similarity described by Park & Kim [3].
Pharma-motifs describe the conservations of binding environments for drug discovery and protein functions.
In the future, the lipid models simulated here can be utilized e.g. in the studies of peptide binding, membrane protein function and lipid membrane fusion.
Zfp36l2, like its better-known relative TTP, is a mRNA-binding and destabilizing protein, functions in the physiological control of female fertility at the level of early embryonic development [ 26].
Since the zinc finger motifs are flexible, with the ability to bind DNA, RNA and/or proteins, changes in the sequences of zinc finger motifs and their number could differentially alter binding specificities and thus protein function.
Moreover, the most enriched GO terms associated with the consistent SDE mRNAs for molecular function were binding and protein binding (Fig. 1D).
In cellular function, DNA binding and protein binding were the most common terms with 18%, and 17% respectively.
Modulation of filament bending and twisting dynamics has been linked to regulatory actin-binding protein function, filament assembly and fragmentation, and overall cell motility.
Currently, we are investigating how myosin elicits cell shape change and how its function is regulated through filament formation, phosphorylation, sub-cellular targeting and small GTP-binding protein function.
Over the last decade, altered RNA regulation and aberrant RNA-binding protein function have emerged as a central theme in motor neuron disease pathogenesis, with evidence suggesting that sporadic ALS disease pathology may overlap with the molecular pathology uncovered in familial ALS.
