Sentence examples for binding and potent from inspiring English sources

A humanized variant, huKM796H/Lm-28, containing eight and five amino acid alterations in variable light (VL) and variable heavy (VH) FRs, respectively, showed a 9-fold reduction in complement-dependent cytotoxicity (CDC) compared to the chimeric KM966, despite tight antigen binding and potent antibody-dependent cellular cytotoxicity (ADCC).

These compounds exhibit low Kd's for binding and potent inhibition but only after a lengthy preincubation period.

NBI 30545 (18n) was found to have good binding affinity and potent antagonistic activity at the human CRF1 receptor.

Among them, 3b exhibited high values of binding affinity and potent agonistic activity for the DOR that were approximately equivalent to those of 2 which bore an oxazatricyclodecane skeleton.

Those ligands which exhibit high AR binding affinity and potent functional activity for human AR may provide effective clinical uses for male fertility, male contraception, and hormone replacement therapy.

Consistent with its specific binding to and potent inhibition of purified CDK9-CycT1 in vitro, i-CDK9 markedly reduced the CDK9-mediated pSer2 in the Pol II CTD and Thr775 (pThr775) in the DSIF subunit SPT5 in a dose-dependent manner in HeLa cells.

On the other hand, compounds 2 and 6 containing acrylamide or vinylsulfonamide groups are reversible towards FLT3 binding, and are potent and selective inhibitors of mutant FLT3-ITD versus wt-FLT3.

In order to find stronger DNA binding and more potent cytotoxic compounds, a series of ester-coupled bisanthrapyrazole derivatives of 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl 7-chloro-2-[2-[ 2-hydroxyethyl

Importantly, the structure provides a foundation for mutagenesis to enhance the binding affinity for cocaine and potent cocaine derivatives, such as cocaethylene, and for additional humanization of the antibody.

The metabolite 6 with an epoxy ring exhibited high anti-aggregative potency with an IC50 of 5.8 nM and potent binding affinity for the human recombinant IP receptor with a Ki value of 6.1 nM and selectivity for human IP receptor over all other members of the human prostanoid receptor family.

Mouse CD8+ T cells transduced with an m33-encoding retrovirus showed binding of SIY-Kb and potent function in vitro, but in vivo these T cells disappeared within hours after transfer into syngeneic hosts without causing graft-versus-host disease (GVHD).