Sentence examples for binding and positioning of from inspiring English sources

We established the causal relationship between NF-Y binding and positioning of methyl marks, by ChIP analysis of mouse and human cells infected with a dominant negative NF-YA: a parallel decrease in NF-Y binding, H3K4me3, H3K79me2 and transcription was observed in promoters that are dependent upon NF-Y.

Further evidence for the role of the dNTP γ-phosphate in binding and positioning of the dNTP for DNA synthesis has been provided by mutation of the K65 residue to abolish the interaction [5] and by modification of the nucleotide γ-phosphate [20].

An accessory RNA subunit R S evolves, driven by selection for increasingly efficient binding and positioning of aminoacyl- T complex on R L (Fig. 12).

Although the key to their catalytic cycle is the fact that binding and positioning of primary substrate precede O2 activation, the means by which substrate binding stimulates turnover is not well understood.

It has been suggested that conserved Tyr17 and Glu120 residues of E. coli TdcF also play a role in substrate binding and positioning of a water molecule used for imine hydrolysis, but replacing the corresponding residues with alanine had little effect on the activity of S. enterica RidA [ 8].

In this 'Adam's rib' scenario, an accessory RNA subunit RS evolves as a tool to enhance binding and positioning of aminoacyl-tRNA on the catalytic subunit, then acquires the "burden of specific recognition," and later on, one of its own parts assumes the role of a diffusible template.

In this regard, because no sequence motif equivalent to the yeast AU-rich efficiency element or the mammalian UGUAN sequence was observed among the putative 3′-end-processing signals in A. oryzae, the RNA-binding specificity and positioning of the homologs Hrp1 and CFIm25 involved in 3′-end-processing in A. oryzae must be investigated.

The spliceosome active site is organized around the U5 snRNA loop 1 and the U2/U6 snRNA duplex [ 34], which are involved in binding and correct positioning of the sites of chemistry in the pre-mRNA substrate (5′SS, 3′SS and BP).

Compared to PWM-based approaches, the k-mer based approaches can be designed to make fewer assumptions about the degree of TFBS degeneracy, length of the binding sites, and position dependences of a motif.

We asked whether the level and position of binding might discriminate between these genes (≥1.5-fold; FDR < 10%) and unaffected target genes.

Identifying mRNA targets is complex because most bioinformatics tools search primarily for complementarity between the short miRNA seed sequence (5′ nucleotides 2 7) and the mRNA, and then take other factors into account, including the free energy of the miRNA-mRNA duplex and position of binding within the 3′UTR.