Sentence examples for binding and phosphorylation of from inspiring English sources

Activated JAKs phosphorylate the receptor domains to allow subsequent binding and phosphorylation of the STAT transcription factors, which in turn translocate into the nucleus to activate gene expression.

Synergy requires receptor phospho-Tyr and two anionic lipids (phosphatidylserine and PIP2) to make PI3Kα competent for bilayer docking, as well as for subsequent binding and phosphorylation of substrate PIP2 to generate product PIP3.

Activation of CaMKIV is a transient, tightly regulated event requiring both Ca(2+)/CaM binding and phosphorylation of the kinase on T200 by an upstream CaMK kinase (CaMKK).

beta-Arrestins are versatile adapter proteins that form complexes with most G-protein-coupled receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein-coupled receptor kinases (GRKs).

Mutation of Adr1 serine 98 affects in vitro and in vivo DNA binding, and phosphorylation of serine 98 in vivo correlates with glucose availability, suggesting that Adr1 promoter-binding is regulated in part by serine 98 phosphorylation.

Mitogen-activated protein kinase (Mapk) kinase (Map2k) kinases (Map3ks) activate Mapks by the binding and phosphorylation of Map2ks.

Our prostate cancer gene signature is associated with a distinct set of processes (nucleic acid processing, TF-binding and phosphorylation of proteins) compared to others that relate to cell-cycle control (Ramos-Montoya et al., 2014; Cuzick et al., 2011) or lipid metabolism (Lalonde et al., 2014).

This was attributed to direct phosphorylation of MLC as well as inactivation of Smooth Muscle Myosin Phosphatase (SMMP-1M), through phosphorylation of the phosphatase's myosin binding subunit, and phosphorylation of its inhibitor protein CPI17 [18], [18].

For comparative purposes, we also analyzed in these experiments the binding properties and phosphorylation of M2P2, a previously described M2 mutant protein that lacks the PRR involved in the recognition of both Vav1 and Fyn [22].

This was further assessed by looking at some markers of meiotic maturation in oocytes, including degradation of cytoplasmic polyadenylation element binding protein and phosphorylation of MAPK and histone H3 serine10.

In case of heterodimerization, HER2 is necessary for ligand binding stabilization and phosphorylation of tyrosine residues that leads to downstream second messenger pathways activation such as those mediated by mitogen activated protein kinase (MAPK), phospholipase-C γ and phosphatidylinositol 3 kinase (PI3K) [ 26].