Sentence examples for binding and orientation of from inspiring English sources

Given these results, Arg301 may be involved in the binding and orientation of the phosphite substrate and/or play a catalytic role via electrostatic interactions.

It is likely that the bridging distance between the two redox active Cys residues and optimal tail flexibility favor catalytically productive binding and orientation of PfTrx.

Such structures are common in Holliday-junction-resolving enzymes, including RecU (PDB ID 1ZP7), and likely play a role in the binding and orientation of substrate (Cañas et al., 2011).

NMR can also be used to provide spatially resolved information about the binding site and orientation of the fragment hits that can be exploited to guide structure-based elaboration of these low-affinity start-points toward more potent and drug-like lead candidates.

This technique has frequently been used to predict the binding affinity and orientation of small drug molecules at the target site.

Molecular modeling simulation of 4e was performed using three-dimensional structure of Torpedo californica AChE (TcAChE) enzyme to disclose binding interaction and orientation of this molecule into the active site gorge of the receptor.

The appropriate binding conformations and orientations of these compounds interacting with cytochrome bc1 were also revealed by molecular docking.

To confirm the binding position and binding orientation of Sal shown in Figure 6B,C, we prepared a bromine-containing Sal derivative, and collected X-ray diffraction data for E. coli RNAP holoenzyme in complex with the bromine-containing Sal derivative.

The mode of binding and the orientation of EMD 57033 in this pocket were further analyzed using a flexible, targeted docking procedure.

However, further analysis on five putatively interacting TF pairs suggests that such interactions may be relatively insensitive to the distance and orientation of binding sites.

This means that the method does not assume that the location and orientation of binding sites is conserved across species.