Sentence examples for binding and neutralization of from inspiring English sources
Consistent with this hypothesis, we observed a 10-fold enhancement in ADI-15946 binding and neutralization of rVSV-EBOV GPW291R compared to rVSV bearing wild-type EBOV GP (GPWT) (Fig. 3d,e and Supplementary Table 1).
We show that relatively few mutations introduced in the 46M2 and 46M3 variants resulted in improved binding and neutralization of SUDV and confirmed the importance of the LC FR3 region to the binding interface.
Our work also mapped the paratope of ADI-15946, thereby explaining reduced activity against Sudan virus, which enabled rational, structure-guided engineering to enhance binding and neutralization of Sudan virus while retaining the parental activity against EBOV and Bundibugyo virus.
We demonstrate the three-dimensional engagement of the apex region of the CDRH3 with the conglomerate of gp41 epitope and membrane lipids as a means of effective binding and neutralization of the virus.
Hybridoma supernatants were collected and screened for antigen binding and neutralization of VEGF/VEGFR-2 interaction.
The anti-inflammatory activity of lactotransferrin is due to binding and neutralization of proinflammatory molecules and its capacity to promote activation of neutrophils and macrophages [56].
As at least one mechanism how BH3-only proteins promote apoptosis is the binding to and neutralization of anti-apoptotic Bcl-2 members, we addressed the question whether thiazolides promote Bim and Puma binding to Bcl-xL and Mcl-1.
Our analysis of the contributions of somatic hypermutation to the binding and neutralization properties of ADI-15946 indicated that only a limited number of amino acid substitutions in the germline antibody sequence were required for binding of this conserved GP site and that many of these mutations occurred in the framework region.
The enhancement of ADI-15946 binding and neutralization in the presence of β17 β18 loop binders such as FVM09 may reflect a mechanism by which specific combinations of glycan cap- and base-binding mAbs can synergize to interdict viral infection during a natural polyclonal immune response (Fig. 4g).
We tested ADI-15946 variants containing alanine substitutions at either the D100C or the L100F positions for binding and neutralization and observed loss of both activities against recombinant vesicular stomatitis virus (rVSV) particles bearing BDBV GP K510E (Fig. 2d).
We examined HIV Env binding (and neutralization) in the context of light chain use in subjects with acute HIV infection, chronic HIV infection, and among HIV vaccinees.
