Sentence examples for binding and multiple sites from inspiring English sources

These problems of promiscuous binding and multiple sites increase the risk of inhibitors also disrupting beneficial interactions.[ 5] The nuclear transporter karyopherin-α/importin-α, which is of increasing interest as an anticancer and antiviral drug target,[ 6] exemplifies many of these problems.

The PPE is able to extract non-trivial sequence and structure signatures that are necessary for capturing the promiscuous process of a drug binding to multiple sites and the sites binding to multiple drugs.

In the second pattern, each protein bound strongly alone, and FruA appeared to be binding to multiple sites.

Genistein has been reported to both activate and inhibit cystic fibrosis transmembrane conductance regulator (CFTR) by binding through multiple sites.

Alternatively, interactions of ligands with protein regions that allow diffuse binding, distributed over multiple sites and conformations, can exhibit favorable Δ G because of their higher entropy.

These findings indicate an additional irreversible binding mode of palonosetron that is distinct from the slowly dissociating binding, and may reflect multiple sites of interaction of palonosetron with 5-HT3 receptors.

The HIV-1 envelope gp120, which features both the virus receptor (CD4) and coreceptor (CCR5/CXCR4) binding sites, offers multiple sites for therapeutic intervention.

To generate versatile cloning vectors harboring genes encoding viral 2A peptides, we inserted four different 2A sequences (P2A, T2A, E2A and F2A; Fig. 1B) [11] into a pCS4+ plasmid, which has a simian cytomegalovirus (sCMV) promoter, SP6 and T7 RNA polymerase binding sites, multiple cloning sites (MCSs) and an SV40 polyadenylation site [14].

However, as previously suggest, replacement of iron by copper, and binding of copper at multiple sites on the protein might lead to aggregation of the protein.

miRNAs regulate target genes by binding to 3' untranslated regions (3'UTRs) of target mRNAs, and multiple binding sites for the same miRNA in 3'UTRs can strongly enhance the degree of regulation.

The conventional point of view is that miRNAs regulate target genes by binding to the 3′ UTRs of target mRNAs, and multiple binding sites for multiple miRNAs in 3′ UTRs can strongly enhance the degree of regulation.