Sentence examples for binding and modulation of from inspiring English sources

These allosteric enzymes present spatially distinct locations for regulation and catalysis and offer oligomeric states where tertiary and quaternary structural changes are transmitted across protein protein interfaces to facilitate the communication between effector binding and modulation of catalytic activity (Ribeiro et al. 2015).

The complexity of wnt signaling likely stems from two sources: multiple pathways emanating from frizzled receptors in response to wnt binding, and modulation of those pathways and target gene responsiveness by context-dependent signals downstream of growth factor and matrix receptors.

In addition, GSTs can serve as peroxidases, isomerases and thiol transferases or have non-catalytic functions such as ligand binding and modulation of signalling processes (for review: [ 99]).

The primary mechanism of estrogen action is via binding and modulation of activity of the estrogen receptors (ERs), which are ligand-dependent nuclear transcription factors.

IFIT1 is typically silent in most cells, but becomes highly expressed in response to interferons, viral infection, and certain molecular patterns, with IFIT proteins having antiviral effects through binding and modulation of host and viral proteins and RNA [ 36].

It is also known that GAG promotes the binding and modulation of growth factors and cytokines and the inhibition of proteases and is involved in the adhesion, migration, proliferation, and differentiation of cells [ 20– 20].

To establish the dependence on CaM for SRY nuclear import, cells were initially transfected to express WT GFP SRY-FL protein and treated 12 h p.t. with the potent and specific CaM antagonist CDZ, a widely used imidazole compound which binds directly to CaM to prevent binding to and modulation of the activity of CaM's various specific binding partners [ 16, 31].

Anesthetics are thought to mediate a portion of their activity via binding to and modulation of potassium channels.

Modulation of TF activity can be achieved via a few different approaches, including direct or indirect modulation of their own expression, modulation of their DNA binding activity, and modulation of their ability to interact with partner proteins (Table  1).

Together with mutagenesis studies and recent GPCR structures, our results provide indications that stabilization is attained through a combination of specific sterol binding to GPCRs and modulation of micelle morphology.

The PKA pathway is activated by the second messenger cAMP which in turn leads to the phosphorylation of the Cre-binding protein (CREB) and modulation of transcription of downstream genes [22], [23].