Sentence examples for binding and modification of from inspiring English sources
It is not fully understood how Met1-polyUb regulates this process, but it involves the binding and modification of the IKK subunit NEMO with Met1-linked chains.
SFN may also affect ternary complex stability through binding and modification of cysteinyl thiol groups of Keap1 (60) but it remains unclear if QTN affects ternary complex stability directly (57).
Antioxidant effects, steroid receptor binding, direct interaction with intracellular elements and signaling systems and, recently, aryl hydrocarbon receptor (AhR) binding and modification of subsequent signaling pathways [ 2- 15] have been proposed as possible mechanisms for the mediation of the oncoprotective effect of these agents.
Otherwise, small association constants values, different sets of binding sites with close association constants, or other phenomena such as protein structural changes induced by ligand binding and modification of ligand solubility in the presence of protein may distort data and cause artifacts (Muresan et al. 2001).
As shown in Fig. 6C, exposure of Granta cells to 30 µM parthenolide for 3 hours resulted in a decrease in phospho-IκB-α, which is highly consistent with the observed effects of parthenolide on p65 DNA binding activity and modification of p65 (Fig. 6A, and 6B, respectively).
The analogous residue in A3F, E127, is not important for HIV-1 Vif binding [71], and modifications of this amino acid in human A3F do not change its recognition by HIV-1 Vif or SIVagm Vif [71].
Proteins with TAZ zinc fingers and BTB/POZ protein binding domains were shown to bind calmodulin and the BET class of chromatin binding and modification proteins that contain a bromodomain [ 95- 98].
Research on the control of Nrf2 has focused on binding and chemical modification of its inhibitor, Keap1, by activators, stabilizing Nrf2 to proteolysis thus increasing cellular Nrf2 protein content (27).
Hitherto regulatory control of the Nrf2 has focused on binding and chemical modification of Keap1 by activators but in an Nrf2 Keap1 binary complex.
Protein phosphorylation influences the activity of transcription factors through diverse mechanisms, such as modulation of their nucleo-cytoplasmic distributions, DNA-binding properties, and protein stabilities and modification of their interactions with other regulatory proteins [ 33, 38, 39].
Mechanisms of resistance to cephalosporins include reduced permeability and modification of penicillin-binding protein, and emergence appears to be rapid.
