Sentence examples for binding and loss of from inspiring English sources

Previous work showed that wild type HLADH has significant kinetic complexity down to −50 °C due to slow binding and loss of substrate [S.-C. Tsai, J.P. Klinman, Biochemistry, 40 (2001 2303]].

It binds with high selectivity to the extracellular domain of IGF-1R (and not to IR), leading to displacement of IGF-1 binding and loss of protein at the cell surface due to receptor internalization and degradation.

In vitro, missense mutations have been shown to result in varying degrees of impaired ACTH signalling, most often by affecting trafficking of the receptor to the cell surface, but also by disruption of ligand binding and loss of signal transduction.

The concurrent reduction in STAT3 transcriptional activity of targets such as survivin through decreased DNA binding and loss of STAT3 phosphorylation likely both played a role in the reduced survival of OSA tumor cells observed following exposure to FLLL32.

A recent in vivo study reported a similar enhancement of lattice binding and loss of end tracking for a Mal3 mutation at the same position (Mal3Q89R; Iimori et al., 2012).

To test for covalent binding and loss of enzyme activity, substrate 1 and epoxide 2 or progesterone control were preincubated with CYP17A1 before dilution and activity assay with pregnenolone substrate.

TDP-43 is a multifunctional RNA binding protein, and loss-of-function of TDP-43 has been increasingly recognized as a key contributor in TDP-43-mediated pathogenesis.

Correct, it's correlation (of loss of binding site and loss of expression of the transcription factor that binds), not causality, so the interpretation is indeed just a plausible suggestion.

The lack of exon 3 in TRAIL- β and of exons 2 and 3 in TRAIL- γ results in massive truncation of the extracellular binding domain and loss of proapoptotic potential.

The most notable change was seen in F1174L mutation which was well supported by an increase in binding energy and loss of hydrogen bond interaction with the neighboring protein when compared to the native protein.

Importantly, owing to the shortened linker region preceding the DNA-binding loop and loss of stabilizing hydrogen bonds (for example between Asp and the DNA-binding loop in CFP1), the DNA-binding interface of the TET3 ZF-CxxC domain is not as rigid as those found in type-1 ZF-CxxC domains.