Sentence examples for binding and initiation of from inspiring English sources

The interaction of PCNA with DNA imparts an orientation to PCNA that is competent for pol δ binding and initiation of DNA synthesis.

In particular, the β-ssDNA contact may function as a 'placeholder' that keeps β-clamp near the 3′ end of primed DNA before polymerase binding and initiation of DNA replication6.

Because ChIP assays revealed no difference in C/EBPβ recruitment to the cebpα and pparγ2 promoters before and after DLK depletion, it is tempting to speculate that DLK action in adipogenesis lies between C/EBPβ DNA binding and initiation of cebpα and pparγ2 gene transcription.

Pioneer transcription factors interact with chromatin and expose DNA for subsequent transcription factor binding and initiation of transcription (Liu et al. 1991; Monaghan et al. 1993).

Thus the remnants are likely to have a role both in binding of precursor membranes and initiation of membrane fusion [6].

At the molecular level, during G1/S, the CDK2 cyclin E complex hyperphosphorylates retinoblastoma protein (RB), which leads to the dissociation of E2 promoter binding factor (E2F) from RB and initiation of E2F transcriptional activity.

However, the transmembrane signaling caused by CTxB binding and the initiation of intracellular processes remains poorly defined, which reveals a critical lack of understanding of fundamental membrane biophysics.

Two follistatin molecules surround activin, blocking both the type I and type II receptor binding sites, thereby preventing receptor binding and the initiation of the signalling cascade [ 36, 37].

Distributions of waiting times between protein injection and initiation of protein binding to DNA (Δ twait) followed single exponential decay with the apparent rate (inverse time constant twait multiplied by 10 nM protein concentration) of 0.49 (μs−1) and 0.53 (μs−1) for RAD52 and RAD52Y104pCMF, respectively.

In this model, degradation is viewed as occurring in two phases: proteasome recognition and binding followed by initiation of polypeptide insertion into the proteolytic chamber.

The cluster with moderate up regulation is enriched with terms of vesicular transport, lipid biosynthetic process, protein complex formation and protein folding, cellular morphogenesis, cytoskeleton binding, initiation of DNA replication, integrin and cell-cell signaling, as well as MAPK and small GTPase signaling.