Sentence examples for binding and initiating the from inspiring English sources

Using full-length recombinant human protein, the results of our kinetic study show that the PKN family of kinases follows an ordered Bi Bi reaction mechanism, where ATP is the first substrate to bind, thus allowing subsequent peptide substrate binding and initiating the phosphotransfer steps.

PARP1 competes with Ku (classical NHEJ) for binding to DSB ends and initiating the alternative NHEJ pathway (38).

These transcription factors bind to their respective putative binding sites and initiate the transcription of type I IFN, which activates auto- or paracrine pathways to initiate the antiviral responses.

Upon binding to a PAMP, TLR3 dimerizes and initiates the binding of its cytosolic Toll-IL-1 receptor to the adaptor protein Toll-IL-1 receptor domain-containing adaptor inducing IFN-β (TRIF), resulting in the association of TLR3 with TRIF.

The NBS domain contains several conserved motifs that are responsible for nucleotide binding and initiating a signal transduction cascade to activate plant defenses (Tameling et al. 2002).

These cytokines are induced through IL1B and TNF-alpha (both increased in lSSc-PAH patients on the cytokine array) and initiate the binding of monocytes to the endothelium.

This suggests that Wolbachia and Anaplasma replication may be quite interesting; experimental work is needed in order to clarify the roles of replication-associated proteins in binding the ori and initiating DNA replication initiation process.

Interaction of drug/substrate in the active site causes a conformational change in the NBDs that enhances ATP binding and initiates dimerization of the NBDs.

Its mechanism of action is thought to be similar to that of thrombopoietin, directly binding to the thrombopoietin receptor and thereby initiating the signaling pathways.

C5aR is expressed in multiple cell types, and binding with C5a initiates the downstream signaling cascades.

At least one of these domains is required for proper transcriptional binding to initiate the canonical UPR transcriptional response.