MUC1 transfection into ES-2 human ovarian tumour cells has been reported to decrease Annexin-V cell surface binding and increase chemoresistance of the cells to anticancer drugs in suspension.
We suggest that under selective pressure, the recent Alu elements mutated in such a way as to strengthen p53 binding and increase the level of the p53-induced repression of Alu transcription (see above).
Also unclear is the effect of this binding and increased phosphorylation of hTTP on its activity or function.
The anti-inflammatory activity of glucocorticoids is mediated at least in part through physical interference of the glucocorticoid receptor complex with NF-κB DNA binding and increased synthesis of IκB [ 36], and there is some evidence of benefit from corticosteroids in the treatment of pneumococcal meningitis and perhaps also severe community-acquired pneumonia [ 37, 38].
ImmunoNPs demonstrated specific binding and increased uptake of the desired cells by means of monoclonal antibodies (MAbs), compared to nonconjugated NPs.
This beneficial effect was associated with increased hepatic tissue TNF-α concentration, enhanced hepatic NF-κB DNA binding and increased expression of cell cycle protein cyclin D1, three important factors in liver regeneration.
Inhibition of OPN leads to increased cell death, increased TUNEL staining, decreased NF-κB binding and increased levels of the inhibitor IκB-α [34].
What is more, these data support the notion that miR-200c interacted with the TUBB3 3′UTR in hypoglycemia and that such an interaction was important for HuR binding and increased expression of TUBB3 under stressing conditions.
The C-terminal tail of CKIε provided some enhancement of xDsh binding and increased the level of phosphorylation by the mutant protein (Fig. 5), but it was not sufficient for binding.
