Sentence examples for binding and functional studies from inspiring English sources
Radioligand binding and functional studies in isolated organs revealed that title compounds present high affinity and antagonistic potency for α1- compound 2 and 8), β-(compounds 1, 3, 4, 7), α1- compoundnds 5 and 6) adrenoceptors.
The binding and functional studies reported here were performed in epithelial HeLa cells, which contain a high endogenous level of AP-1 transcription factors [47], because we could not observe PMA-mediated activation of AP-1 in the two other cell lines used (Jurkat and U937) despite many attempts (data not shown).
Therefore, MCF-7 and A764 cells were selected for in vitro and in vivo binding and functional studies.
The data from extensive mutagenesis, binding and functional studies reveal the importance of these residues and also provide a structural explanation for their critical roles.
As the binding and functional studies give different results, it is possible that these ligands also bind elsewhere or they are slow to reach equilibrium, meaning that current responses desensitize before the full antagonist effects are seen, a property that could particularly influence inhibition at the more rapidly desensitizing 5-HT3AB receptor.
Binding and functional studies revealed that these hydrogen-bond donor containing compounds exhibit improved affinity and selectivity for the α7 nAChR subtype and demonstrate partial agonism.
In the present study we analyzed A2A and A2B AR subtypes in neutrophils from patients affected by SSc by means of expression analysis, radioligand binding assays and functional studies.
In the present study we analyzed A2A and A2B AR subtypes in neutrophils of patients affected by SSc, by means of Western blot, radioligand binding techniques and functional studies.
Future research should include the description of possible binding sites in the conserved elements and functional studies of those putative regulatory elements found by in silico analyses.
Chang et al. report structural and functional studies of Norrin, its binding partner Fz4CRD, and the Norrin:Fz4CRD complex.
To assess our putative binding site for GAGs, we performed structure-guided mutagenesis and functional studies.
