Sentence examples for binding and function with from inspiring English sources

As shown in this study, structure-based analysis of specific mutations that alter the binding and function with defined chemical changes is needed to understand the functional mechanism of protein-protein interactions between IL-3 and its receptor.

Elevated cortisol levels might account for the reduction in central serotonin 1A (5-hydroxytryptamine [5-HT]1A) receptor binding and function observed in patients with major depression.

In the present study, we demonstrate that OLA1 protects cells from heat shock by interfering with the binding and function of the E3 ligase CHIP to HSP70, leading to stabilization of HSP70.

Nancollas and colleagues documented that the R2 side chain determines this binding function, with the following binding differences: zolendronate > alendronate > ibandronate > risedronate.

The physical separation of the binding and catalytic functions of R – with the binding/recognition of aminoacyl- T RNAs now relegated to R S and the transpeptidation reaction remaining the function of R L – provides for the separate evolution and elaboration of the respective activities (a situation that could be viewed as a distinct type of subfunctionalization).

Such regulatory mechanisms may link N-CAM binding function with other primary cellular processes during the embryonic development of pattern.

Figure 1A shows GO functional groups for known transcripts represented on the AH006 array and a detailed description of the GO molecular function (MF) cluster is displayed in Figure 1B which indicates uniform distribution of probes with binding and catalytic functions.

Acetylation patterns are transmitted and interconnected with protein binding ability and functions in subsequent cell generation.

The Medicago gene has 40% identity and 58% similarity to the A. thaliana protein and also contains both of the conserved domains that were shown to function in binding and interaction with other proteins, namely the BTB/POZ and ankyrin repeats domains [49].

Despite their inability to form a unique stable tertiary structure in isolation, many IDRs adopt a defined conformation upon binding and achieve their function through their interactions with other biomolecules.

For instance, omacetaxine treatment appeared consistent with reduced cell division and increased apoptosis while increased kinase binding and vacuole-related functions were associated with an up regulation in response to imatinib.