Sentence examples for binding and folding of from inspiring English sources

The significant coupling between the binding and folding of biomolecules often exists in many important cellular processes.

[27] At the same time, induced-fit and fly-casting mechanism was given to explain the binding and folding of pKID-KIX complex.[28] Nevertheless, all atomic MD models can provide more detail information about the folding and binding kinetics of the complex.

Our results show that both the C-terminal tail and the WHD constitute a linker histone fold-binding domain and are necessary for proper binding and folding of the chromatin fibre.

In this study, we probed the effects of a few key mutations on the coupled binding and folding of α-synuclein by using a combination of single-molecule (smFRET) and ensemble (far-UV CD) measurements.

The observed differences between a fully exposed single-stranded aptamer and an aptamer embedded in a stem-loop conformation should reflect thermodynamic competition between a Watson Crick base-pairing configuration, and the induced denaturing of the duplex by ATP binding and folding of the single-stranded aptamer.

Binding and folding of substrate proteins by the molecular chaperone GroEL alternates between its two seven-membered rings in an ATP-regulated manner.

The number of cases on which NF-κB detection (both DNA binding and fold of activation of DNA binding) was completed with controls for comparison was 67 children (Fig. 2).

Mixed mechanisms of course are possible, with a subregion of the interface interacting via conformational selection, followed by concomitant binding and folding for the remainder of the interface.

In this Opinion article, we point out the importance of coupled binding and folding for protein protein signalling interactions generally, and from this and associated observations, we develop a new strategy for identifying protein protein interactions that would be particularly promising targets for modulation by small molecules.

Alternatively, a local part of the binding region could form an interaction followed by concomitant binding and folding over the remainder of the interface [ 5- 7].

An important output of induced folding is that this coupled binding and folding determines a unique combination of high specificity and low affinity [ 107] typical of the signaling and regulation interactions.