In agreement with our analysis above, the functional enrichment analysis shows a clear differential regulation of transcriptional units, including transcription factor and cofactor binding, repressor activity and enzyme binding.
The top GO molecular functions enriched in the gene set relate to protein binding, nucleotide binding, and enzyme activity (eg. hydrolase, phosphatase, decarboxylase).
Genes that were associated with nucleic acid binding TFs activity, DNA binding, phosphatase activity and enzyme activity had binding profiles that were highly correlated between the wild-type and mutant strains.
Only GOPred and PFP tools gave predictions in correlation with the function reported in the literature, which were enzyme activator activity, enzyme binding, and purine nucleotide binding.
Thus, we present four DMO structures with resolutions ranging from 1.95 to 2.2 Å, which, in sum, provide a snapshot of a dynamic enzyme where metal binding and substrate binding are coupled to observed structural changes in the non-heme iron and catalytic sites.
Finally, about the molecular functions, there are enzyme binding, protein binding and nucleotide binding, which are very different from the early stage bladder cancer.
The top three over-represented GO terms are enzyme activity, nucleic acid binding and other binding.
The largest group consists of binding functions, specifically nucleotide binding, protein binding, and sugar binding.
IEA annotations are generalised to apply to a diverse range of species and usually only represent very broad functions such as 'Protein binding' and 'Enzyme binding'.
The four analog mechanisms map to enzyme induction, enzyme elimination, drug metabolism, and enzyme-substrate binding.
