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We continue by outlining the progress that has been made in identifying the functional significance of different types of interactions, for example, in subserving stimulus binding and enhancement of perceptual certainty.
Glued is the largest subunit of dynactin complex and plays a particular important role in dynein binding and enhancement of dynein processivity.
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Owing to results from the binding capability and enhancement of catalytic function when fused to CelE, we further studied the binding properties of four CBMs: CBM3a; CBM6; CBM30; and CBM44.
The clinical actions of benzodiazepines are thought to be mediated via specific allosteric benzodiazepine binding sites and enhancement of GABAergic neurotransmission in the brain.
Importin β alone had no effect on in vitro RNMT activity, but inhibited importin α binding to RNMT and enhancement of RNMT activity.
Twist expression in breast cancer cells has been shown to result in resistance to paclitaxel through binding to Akt promoter and enhancement of its transcriptional activity [ 26], as well as resistance to other microtubule-targeting agents such as vincristine [ 27, 28].
Based on both the similarity of the thermodynamic signatures for gp120 binding and the enhancement of entry in the absence of cell-associated CD4, we termed NBD-556 a small molecule CD4 mimetic.
97 Splicing mechanism studies on model genes have deduced many regulatory principles including the role of negative intrinsic sites binding and positive enhancement of splicing sites selection in the formation of spliceosome assembly.
The recent finding that pRB induces Sp1 activity by binding to mdm2 resulting in the physical release of Sp1 from mdm2 and enhancement of its binding to consensus sequence implies that mdm2 might inhibit promoters such as hTR that are positively regulated by pRb and Sp1 [ 15].
Recent studies conducted in smooth muscle cells have led to a model (for review see [ 21, 22]) that associates RhoA with contraction via activation of Rho kinase (ROCK) and ROCK-dependent phosphorylation of myosin phosphatase, thereby inactivating it and resulting in an increase in the phosphorylation state of myosin light chain and enhancement of myosin binding to actin filaments.
One of the roles of cytoplasmic HMGB1 is the detection of nucleic acids and enhancement of nucleic acid binding TLRs activation.
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