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Further research for therapeutic interventions is warranted in several areas such as binding and elimination of endotoxin by extracting the source of sepsis, blocking of various apoptotic pathways, or even extracorporeal removal of circulating toxic mediators using high volume hemofiltration, high permeability hemofiltration and plasma filtration coupled with adsorption [85].
The mechanisms by which S. boulardii exerts its protective effects are diverse, including proteolytic cleavage of Clostridium difficile toxins A and B [13], [14], inhibition of cholera toxin stimulated cAMP production [15], binding and elimination of cholera toxin [16], and interference on bacterial-stimulated cellular signaling pathways [17] [20].
First, immediately upon administration of the vector particles, pre-existing humoral immunity can lead to antibody binding and elimination of the vector particles, preventing them from ever reaching the target tissue.
Further research for therapeutic interventions is warranted in several areas such as binding and elimination of endotoxin by extracting the source of sepsis, blocking of various apoptotic pathways, or even extracorporeal removal of circulating toxic mediators using high volume hemofiltration, high permeability hemofiltration and plasma filtration coupled with adsorption [ 85].
The study of Mariano and colleagues additionally opens directions for research on therapeutic interventions mitigating septic AKI, including the binding and elimination of endotoxin in the gut, the blocking of apoptotic pathways and the extracorporeal removal of circulating pro-apoptotic mediators.
These include the binding and elimination of the source of endotoxin by selective decontamination of the digestive tract, the blocking of apoptotic pathways, or the extracorporeal removal of circulating toxic mediators using high permeability hemofiltration or coupled plasma filtration and absorption.
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EDCs are considered to be exogenous agents that interfere with the synthesis, secretion, transport, binding, action, and elimination of natural hormones in the body responsible for the maintenance of homeostasis, reproduction, development, and behavior.
Protein binding and elimination that influence the disposition of chemicals are also depicted.
The running buffer's composition is one of the main factors in developing a biosensor because it has a significant impact on the efficiency of antibody antigen binding and the elimination of nonspecific adsorption.
We used a target-mediated drug disposition (TMDD) model to characterize SAP depletion in terms of receptor-ligand binding and subsequent elimination of bound SAP (see Figure 3).
25 Its protein binding and elimination kinetics help to explain its long duration of action.
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