Sentence examples for binding and efficacy from inspiring English sources
Therefore, it is unlikely that the differences between varenicline and cytisine on ICSS thresholds are due to differences in nAChR binding and efficacy.
Structural studies underway are determining the site of interactions between the compounds and ERK proteins to better understand the mechanisms of inhibition and identify chemical features that can be modified to improve inhibitor binding and efficacy.
They confirmed previous results, finding that mir-152 and mir-148a bound to HLA-G 3′UTR and downregulate its mRNA, but they also found that the C/G polymorphism at +3142 has no effect on miRNAs binding and efficacy [ 59].
For example, the 3D structure of a microRNA target complex is crucial for understanding microRNA's binding affinity and efficacy in gene regulation (Kertesz et al. 2007; Bartel 2009).
Hydrogen bonds and hydrophobic interaction played a critical role in stabilizing protein-ligand complexes and therefore contributed significantly to improving binding affinity and efficacy of the antimicrobial [ 30].
It should be noted that ideally, to make the above conclusion, the analysis should involve the in vitro and in vivo data from a series of EPOR agonists, including both partial and full agonists, with a range of receptor binding affinity and efficacy.
Within ECL1 and its associated TM regions are key residues that regulate both the binding and the efficacy of αCGRP.
Other factors, rarely taken into consideration, for instance RBPs, may also influence siRNA binding and silencing efficacy [ 13].
To test whether these ASV have biologic activity, we characterized a subset of them for ligand binding, and for efficacy in an animal model of arthritis.
The use of SPR not only overcomes these limitations but also allows the more accurate statistical analysis of the correlation between the degree of binding and drug efficacy.
