Sentence examples for binding and disruption of from inspiring English sources

Rho GTPases activate formins through direct binding and disruption of an autoinhibitory mechanism mediated by regulatory domains that flank the actin/microtubule-binding formin homology-2 (FH2) domain [1].

Furthermore, the binding and disruption of functional receptors such as N-methyl d-aspartate receptors (NMDARs) may also be lipid raft dependent [ 97].

Mutational analysis of the E7 protein shows that the ability of E7 to induce tetrasomy is separable from both pRb binding and disruption of keratinocyte differentiation, indicating that this phenomenon is not directly related to either of these properties and is likely to require multiple functions of the E7 protein.

Like other β-lactams, carbapenems have time-dependent bactericidal activity that results from avid binding to penicillin-binding proteins and disruption of bacterial cell wall synthesis.

Several mutations in human CytB have been related to exercise intolerance [ 12] (Table 1; Figure 9), all of which have similar chemical effects including a change in the net charge around the heme groups and in the binding pockets and disruption of local secondary structures close to the substrate binding areas.

Disruption of either motif (WB6m1 and WB6m2) resulted in a dramatic decrease in binding affinity, and disruption of both motifs resulted in a complete loss of PhoP binding (WB6m3).

This increased proinflammatory state was associated with ileal mucosal barrier loss as demonstrated by decreased levels of the intestinal fatty acid binding protein and disruption of the tight junctional protein ZO-1.

The mechanism by which TBT affects mollusc species remains unclear, although hypotheses have been raised related to binding to and disruption of a putative molluscan RXR or RXR/peroxisome proliferator-activated receptor (PPAR) heterodimer [ 29, 37– 47].

The DNaseI sensitivity of the remodeled filament indicates that the ssDNA is more accessible, and it is therefore possible that the remodeling induced by Rad51 paralogs exposes the ssDNA to facilitate homology probing after filament binding to and disruption of the donor duplex.

A novel scaffold offered considerable insights into the structural basis for binding to LRP5/6 and disruption of the sclerostin-mediated inhibition of Wnt signaling.

In either event, the protein kinase activity of Pak2 requires ATP binding, autophosphorylation of Thr402 and disruption of the autoinhibition to obtain an active conformation.