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Adjacent to the MADS-box is a 29-amino acid extension, referred to as the MEF2-specific (MEF2s) domain, which contributes to high-affinity DNA binding and dimerization with other homologous MEF2 proteins and facilitates interactions with other cofactors [9], [10].
Activation of HER3 is believed to rely on ligand binding and dimerization with other ERBB family members.
Apart from these domains, important for DNA binding and dimerization with HIF-1β, respectively, a central oxygen-dependent degradation domain and two transactivation domains, the N-terminal activation domain (NAD) and C-terminal activation domain (CAD), are recognized in their structures [4].
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In particular, comparison of the DNA binding and dimerization domains of SlmA with QacR yielded a root mean squared deviation (RMSD) of 1.9 Å and 3.9 Å, respectively.
Further, in vitro and ex vivo studies have shown that GAG binding and dimerization are coupled, and that the dimer binds GAGs with higher affinity [33] [35].
(c) The DNA binding and dimerization domains of BES1 (1–89) and RD26 (1 140) interacts with each other.
The inserted sub-domain is shown to be involved in substrate binding and dimerization.
The N-terminal region of the receptors is involved in membrane localization, ethylene binding, and dimerization.
This derivative retains LR1, nuclear localization sequence (NLS), and the DNA-binding and dimerization domains.
It has been proposed that heparin binding site and dimerization of serglycin core together with glycosaminoglycan chains regulate the binding of serglycin with other molecules [ 23, 29].
The RUNX family is highly conserved in their runt homology domain, which is utilized for DNA-binding and hetero-dimerization with the common cofactor CBF β.
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