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To establish which portion of the C-terminal domain carries the DNA binding and dimerization activities, three constructs expressing HA-tagged derivatives of the human CENP-C regions, 638/943 (MII+IIII+III domains), 638/819 (Mif2p homology domain II) and 760 943 (Mif2p homology domain III) respectively (Figure 2), were generated and used in four different assays.
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Some of these motifs have been characterized in animals regarding specificity in the DNA-binding sequence recognition and dimerization activities responsible for the activation or repression of target genes or for binding to small molecules [ 1].
We found that each subgroup (except for D and F with few members identified) of bHLH transcription factors has its own specific GO term categories (Table 2), when common GO terms of transcription such as transcription regulator activity, regulation of transcription, and DNA binding and protein dimerization activity are discounted.
This region holds DNA binding activity and can be responsible for protein binding and dimerization [ 34, 35].
(c) The DNA binding and dimerization domains of BES1 (1–89) and RD26 (1 140) interacts with each other.
The inserted sub-domain is shown to be involved in substrate binding and dimerization.
The N-terminal region of the receptors is involved in membrane localization, ethylene binding, and dimerization.
15, 23 It stimulates proliferation of endothelial cells, through binding and dimerization of cell surface receptors.
This derivative retains LR1, nuclear localization sequence (NLS), and the DNA-binding and dimerization domains.
These are unified by the modified structure of their connector arm, ligand-binding and dimerization pattern.
NFIB is a transcription factor that contains a DNA-binding and dimerization domain [87].
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