Sentence examples for binding and dimerisation domains from inspiring English sources
Despite high sequence conservation within their DNA binding and dimerisation domains, and having very similar DNA recognition specificities, the homologues are functionally non-redundant and biologically essential.
While HIF-1alpha and HIF-2alpha subunits are highly homologous and structurally similar in their DNA binding and dimerisation domains, they have distinct roles both during development [13] [15] and in adaptive responses to hypoxia [8], [11], [16], [17].
The TFAP2A gene consists of seven exons with the last six exons encoding the majority of the protein, including the activation, DNA binding and dimerisation domains [ 1].
NFI-B3 is a naturally truncated isoform that includes the DNA binding and dimerisation domains also present in the other NFI family members, although experimental evidences suggest that it cannot bind to DNA by itself.
In the E protein, two pan-WNV sequences correspond to the fusion loop and dimerisation domain [37], while two correspond to immunoglobulin-like domain, attributed to putative receptor binding sites [38].
The kinase's N-lobe and dimerisation domain do not participate in RhoE interactions.
HIF2α is closely related to HIF1α, with similarities in DNA binding and dimerisation, but with differences in transactivation domains [ 49].
The hormone-binding domain is located in the E region and contains, besides the binding domain, a dimerisation domain and a hormone-dependent transactivation function (AF-2).
The generation of Hif1α ΔIEC involves deletion of exon 2, which contains sequences encoding the basic helix-loop-helix (bHLH) domain that is essential for DNA binding and dimerisation of HIF1α and HIF1β (Jiang et al., 1996), and that results in downregulation of HIF1α-target genes (Iyer et al., 1998; Ryan et al., 1998).
As suggested by structural studies [ 21] both ligand binding and dimerisation activities of the ER monomer are located within its ligand-binding domain (LBD), with ligand binding cavity and ER dimerisation surface spatially separated from each other.
